The attack was scheduled to take place on Saturday, but several Shrewsbury players and personnel tested positive for Covid-19.
The Football Federation’s professional game board will meet early next week to learn what will happen in the game.
A on Southampton’s online page said: “The third circular setting of the Southampton FA Cup at home opposite Shrewsbury Town will not pass as planned on Saturday.
“The club reported the football federation resolution this morning after several Shrewsbury players and staff tested positive for Covid-19. “
Shrewsbury said they had “reluctantly” informed the FA that they would not be so well after a medical opinion indicated that it would be harmful for the attack to occur.
League One club has not exercised since last week and has closed its exercise track at Sundorne Castle for 10 days.
Rachel Robinson, Shropshire Director of Public Health, said on the club’s official website: “We have been informed of positive Covid-19 cases at the Shrewsbury Town Football Club.
“We are working hard with the club to restrict any additional potential spreads. All positive cases, as well as close contacts, are self-insulated for at least 10 days according to national guidelines. “
“The club acted with responsibility and took all precautions to restrict the spread of the virus, which in this case required the closure of the education floor and the isolation of all nearby contacts.
“The club also follows all the government’s elite sports protocols, which come with normal testing of players and staff. “
Southampton had his own considerations last week after goalkeeper Alex McCarthy took a coronavirus test and missed his team’s victory over Liverpool.
Shrewsbury’s added: “The fitness and protection of all Shrewsbury Town Football Club staff remains paramount and the club continually takes all necessary measures to protect everyone when possible. “
Elsewhere, Aston Villa and Middlesbrough have had their arrangements for their third-round matches interrupted through a series of tests.
Villa, who will receive his Premier League opponents in Liverpool on Friday night, closed his Bodymoor Heath education flat after revealing that a “large number” of players had already contracted the virus.
One issue Thursday afternoon read: “Aston Villa can verify that the Club has closed its Bodymoor Heath educational apartment after a primary outbreak of coronavirus. “
“A lot of players and first-team workers tested positive after being screened on Monday and promptly switched to isolation.
“A circular moment of testing carried out without delay and produced more positive effects today.
“The first team before tomorrow’s FA Cup match against Liverpool has been cancelled.
“Discussions are ongoing between club representatives, the Football Federation and the Premier League. “
Villa’s announcement came hours after Boro, who visited Brentford on Saturday, showed evidence.
The Sky Bet Championship club, whose manager Neil Warnock tested positive last year, closed its education headquarters at Rockliffe Park well on Monday after the first-team and players were confirmed, and a new test run, which also included under-23 players. took place on Thursday morning with the expected effects before the weekend.
Derby general manager Stephen Pearce demonstrated Wednesday that the club would send an organization of 23 and 18 players to play in the FA Cup at Chorley on Saturday following a coronavirus outbreak that closed its education field.
Wayne Rooney and the entire Derby first team will miss the third-round draw in Lancashire, and Pearce revealed that nine players and this bubble tested positive for Covid-19.
Meanwhile, Manchester City have shown that their fit of the Women’s Super League against West Ham this weekend has been postponed due to coronavirus testing at the club.
City was due to play West Ham at home on Saturday, but after four players or staff tested positive, the game was cancelled, the club said.