Malaria is one of the main fitness disorders facing emerging countries today. Today, prevention and repair methods are continually hampered by disorders of the increasing resistance of parasites to newly brought drugs, abundant prices and logistical disorders. The main hope of turning this scenario would be the progression of effective vaccines against malaria. A vital component of this procedure is to perceive the mechanisms of naturally acquired immunity against malaria. This review will highlight the key facets of malaria immunity, which are strangely little known and will be essential in the search for effective malaria vaccines.
We thank D. Brown and G. Kassiotis for the critical review of the manuscript. With the support of the Medical Research Council (UK), the Wellcome Trust and the European BioMalPar Network of Excellence (EU: LSHP-CT-2004-503578).
Parasitology Division, National Institute for Medical Research, London, NW7 1AA, United Kingdom
Jean Langhorne, Francis M Ndungu and Anne-Marit Sponaas
Kenya Medical Research Institute – Wellcome Trust Collaboration Project, Kilifi, Kenya
Kevin Marsh
Release date: July 2008
DOI: https://doi.org/10.1038/ni.f.205