The visitors, on the other hand, are in their first problems at an organisational level, after losing to Brann on matchday one.
Lyon are one of the favourites to win the Champions League this season, having won the festival a record 8 times, the most recently in the 2021-22 season.
The French champions deserve to dominate a friendly group consisting of Slavia Prague, St Polten and Brann.
They showed their additional quality on matchday one by beating Slavia Prague 9-0, with five of those goals scored before the 25th minute.
Sara Dabritz, Danielle van de Donk, Vanessa Gilles, Eugénie Le Sommer and Kadidiatou Diani all discovered the ball in a thrilling stretch of play, before the latter added her attacking moment just before half-time.
Ada Hegerberg and Amel Majri scored twice in as many minutes, and Gilles still had time to complete his brace.
After beating Dijon 4-1 on Friday, Lyon have won all 10 of their competitive matches this season, racking up 46 goals and conceding 4 times.
Meanwhile, St Polten are at Champions League level after beating PAOK and Valur in the knockout stages.
While Lyon are expected to win the group, St Polten is battling with Slavia Prague and Brann for a place.
However, their hopes of reaching the quarter-finals were put on the back burner last week when they suffered a 2-1 defeat at home to Brann.
Maria Mikolajova found the net in the 68th minute to disallow Rakel Engesvik’s opener, but St Polten could come from behind for a second time after Natasha Anasi scored what proved to be the winning goal.
Although St Polten bounced back with a 7-0 win over Grazer AK in the Frauen OFB Cup, St Polten are aware of the omnipotent challenge that awaits them in Wednesday’s clash against a Lyon side who scored goalless.
Lyon is without Delphine Cascarino, who has been absent for a long time and is recovering from an anterior cruciate ligament injury.
Le Sommer is expected to be fit to start despite missing Friday’s league game due to a knock in the Champions League win over Slavia Prague.
After rotating her squad for the win against Dijon, Lyon boss Sonia Bompastor can return to the starting eleven that faced Slavia Prague.
On the visitors’ side, German goalkeeper Carina Schulter will prepare for a busy night against the record Champions League champions.
Schulter will look at herself from a base that is expected to come with Julia Tabotta, Diana Lemesova, Jennifer Klein and Ella Touon.
After playing the final 33 minutes against Brann, Rita Schumacher could be tasked solely with leading the line.
Lyon Women’s Imaginable Starting XI: Endler; Carpenter, Gilles, Renard, Morroni; Van de Donk, Horan, Dabrit; Summer; Diani, Hegerberg
Possible St Polten women’s XI: Schluter; Tabotta, Lemesova, Klein, Touon; Mattner-Trembleau, Mikolajova, Johanning, Wenger, Zver; Schumacher
Lyon have scored at least four goals in each of their last six competitive matches and will once again demonstrate their dominance in Wednesday’s home clash against the Austrian champions.
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