Borussia Dortmund had a small merit in the knockout round of the Champions League, but Paris Saint-Germain will hope to make the most of the away goal of their 2-1 defeat.
A brace from Erling Haaland on either side of a Neymar goal put the Bundesliga side out of this tie.
The game is expected to be played behind closed doors as part of ongoing efforts to slow the spread of the coronavirus.
PSG have been in impressive form since the first leg, scoring thirteen goals in 3 games and beating Lyon 5-1 in the Coupe de France semi-finals last time around.
Dortmund have also played and won 3 matches since their last meeting with the Ligue 1 leader, now following Bayern Munich by 4 points at the top of the German table.
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Marco Verratti and Thomas Meunier are suspended for the time being, and Belgian right-back Meunier admitted he did not know he risked being suspended before being warned at Dortmund.
Defensive pair Thiago Silva and Colin Dagba are also undecided, with Silva facing an overdue form check to be in position for the game.
PSG eleven: Navas; Kehrer, Kimpembe, Bernat, Gueye, Marquinhos, Paredes, Sarabia, Di Maria, Cavani, Neymar.
Captain Marco Reus has been out since early February due to a muscle injury, while midfielder Thomas Delaney is also unavailable.
Borussia Dortmund eleven: Burki; Piszczek, Hummels, Zagadou; Hakimi, Can, Witsel, Guerrero; Sancho, Haaland, Hazard.