The Russians sit lately in the current position in the table, one point above Porto and five points behind leaders Atlético de Madrid.
However, Porto’s victory would see the Portuguese champions qualify for the knockout stages again.
Zenit secured a 1-0 late win when the groups met at the Estadio do Dragao two weeks ago.
Axel Witsel missed the match due to a sanction from the home team, while the visitors were harmed by the penalty of Héctor Herrera.
Recent form
Zenith: WWWWLD
Porto: LWWLWD
Possible compositions
Zenith: Lodygin; Smolnikov, Neto, Lombaerts, Criscito; Faizulin, Shirokov, Shatov; Arshavin, Danny; Pontoon
Porto: Helton; Otamendi, Mangala, Danilo, Sandro; González, Fernando, Ghilas, Varela; Martinez, Pereira
Topo Deportivo says: 2-2